Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

In Parkinsons disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra
pars compacta is associated with Lewy bodies arising from the accumulation of alpha …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive
degeneration of midbrain neurons (MBNs). Recent evidence suggests contribution of the …

Variants at the GBA locus, encoding glucocerebrosidase, are the strongest common genetic
risk factor for Parkinson's disease (PD). To understand GBA-related disease mechanisms …

Accumulating evidence support a causal link between Zika virus (ZIKV) infection during
gestation and congenital microcephaly. However, the mechanism of ZIKV-associated …

Motor symptoms in Parkinson's disease (PD) are tightly linked to the degeneration of
substantia nigra dopaminergic neurons and their projections into the striatum. Moreover, a …

Abstract Background The c. G6055A (p. G2019S) mutation in leucine-rich repeat kinase 2
(LRRK2) is the most prevalent genetic cause of Parkinson's disease (PD). CRISPR/Cas9 …

Background Mutations in LRRK2 are the most common cause of autosomal dominant
Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is …

Abstract α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial
and 'sporadic'Parkinson's disease. We previously identified α-helically folded αSyn …