Intracellular mRNA transport and localized translation
Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …
precise temporal and spatial control of gene expression. High-resolution imaging …
In the right place at the right time: visualizing and understanding mRNA localization
The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …
structural asymmetries in cells. Recent research has furthered our understanding of how …
Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs
X Chen, D Zhang, N Su, B Bao, X Xie, F Zuo… - Nature …, 2019 - nature.com
Abstract Fluorescent RNAs (FRs), aptamers that bind and activate fluorescent dyes, have
been used to image abundant cellular RNA species. However, limitations such as low …
been used to image abundant cellular RNA species. However, limitations such as low …
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
JL Bell, K Wächter, B Mühleck, N Pazaitis… - Cellular and molecular …, 2013 - Springer
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2,
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies …
The central dogma decentralized: new perspectives on RNA function and local translation in neurons
CE Holt, EM Schuman - Neuron, 2013 - cell.com
The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …
remote dendritic and axonal compartments makes the use of decentralized cell biological …
Keratins are asymmetrically inherited fate determinants in the mammalian embryo
HYG Lim, YD Alvarez, M Gasnier, Y Wang, P Tetlak… - Nature, 2020 - nature.com
To implant in the uterus, the mammalian embryo first specifies two cell lineages: the
pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms …
pluripotent inner cell mass that forms the fetus, and the outer trophectoderm layer that forms …
Visualization of dynamics of single endogenous mRNA labeled in live mouse
The transcription and transport of messenger RNA (mRNA) are critical steps in regulating
the spatial and temporal components of gene expression, but it has not been possible to …
the spatial and temporal components of gene expression, but it has not been possible to …
Live cell imaging of single RNA molecules with fluorogenic Mango II arrays
RNA molecules play vital roles in many cellular processes. Visualising their dynamics in live
cells at single-molecule resolution is essential to elucidate their role in RNA metabolism …
cells at single-molecule resolution is essential to elucidate their role in RNA metabolism …
Glutamate-induced RNA localization and translation in neurons
Localization of mRNA is required for protein synthesis to occur within discrete intracellular
compartments. Neurons represent an ideal system for studying the precision of mRNA …
compartments. Neurons represent an ideal system for studying the precision of mRNA …
Mapping translation'hot-spots' in live cells by tracking single molecules of mRNA and ribosomes
Messenger RNA localization is important for cell motility by local protein translation.
However, while single mRNAs can be imaged and their movements tracked in single cells, it …
However, while single mRNAs can be imaged and their movements tracked in single cells, it …