Type 2 diabetes is a challenge in modern healthcare, and animal models are necessary to
identify underlying mechanisms. The Nile rat (Arvicanthis niloticus) develops diet-induced …

Background This work elucidates the first cellular and molecular causes of cataractogenesis.
Current paradigm presupposes elevated blood glucose as a prerequisite in diabetic …

Abstract Background The Nile rat (Avicanthis niloticus) is an important animal model
because of its robust diurnal rhythm, a cone-rich retina, and a propensity to develop diet …

Ethnopharmacological relevance Baicalein (BAI) is the crucial flavonoid component in
Scutellaria baicalensis Georgi, possessing biological functions such as anti-oxidant, anti …

Although cataract is the leading cause of blindness worldwide, the detailed pathogenesis of
cataract remains unclear, and clinically useful drug treatments are still lacking. In this study …

Diabetic nephropathy (DN) is a major healthcare challenge for individuals with diabetes and
associated with increased cardiovascular morbidity and mortality. The existing rodent …

Cataract is an eye disease, in which the lens becomes opaque, causing vision loss and
blindness. The detailed mechanism of cataract development has not been characterized …

Type 2 diabetes mellitus (T2DM) is the most common endocrine disorder (90%) in the world;
it has numerous clinical, immunological, and genetic differences from type 1 diabetes …

Regulation of ion and water microcirculation within the lens is tightly controlled through
aquaporin channels and connexin junctions. However, cataracts can occur when the lens …

昼间啮齿类动物具有与人类相似的昼夜节律, 随着生物钟的发现, 近年来此类动物逐渐展露出
夜间啮齿类动物所不能替代的优势, 以新兴模型的姿态出现在代谢, 光反应, 神经调节 …