Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

G Li, E De Clercq - Nature reviews Drug discovery, 2020 - nature.com
Therapeutic options for the 2019 novel coronavirus (2019-nCoV) Skip to main content Thank
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Type 1 interferons as a potential treatment against COVID-19

E Sallard, FX Lescure, Y Yazdanpanah, F Mentre… - Antiviral research, 2020 - Elsevier
Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a
clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the …

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 …

PD Monk, RJ Marsden, VJ Tear, J Brookes… - The Lancet …, 2021 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
carries a substantial risk of severe and prolonged illness; treatment options are currently …

Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

W Alhazzani, MH Møller, YM Arabi, M Loeb… - Intensive care …, 2020 - Springer
Background The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting …

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

TP Sheahan, AC Sims, SR Leist, A Schäfer… - Nature …, 2020 - nature.com
Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a
severe respiratory disease associated with more than 2468 human infections and over 851 …

Compounds with therapeutic potential against novel respiratory 2019 coronavirus

MA Martinez - Antimicrobial agents and chemotherapy, 2020 - Am Soc Microbiol
Currently, the expansion of the novel human respiratory coronavirus (known as SARS-CoV-
2 [severe acute respiratory syndrome coronavirus 2], COVID-2019 [coronavirus disease …

[HTML][HTML] Associations between immune-suppressive and stimulating drugs and novel COVID-19—a systematic review of current evidence

B Russell, C Moss, G George, A Santaolalla… - …, 2020 - ncbi.nlm.nih.gov
Background Cancer and transplant patients with COVID-19 have a higher risk of developing
severe and even fatal respiratory diseases, especially as they may be treated with immune …

COVID-19: drug targets and potential treatments

C Gil, T Ginex, I Maestro, V Nozal… - Journal of medicinal …, 2020 - ACS Publications
Currently, humans are immersed in a pandemic caused by the emerging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …

A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19

B Cao, Y Wang, D Wen, W Liu, J Wang… - New England journal …, 2020 - Mass Medical Soc
Background No therapeutics have yet been proven effective for the treatment of severe
illness caused by SARS-CoV-2. Methods We conducted a randomized, controlled, open …

A randomized clinical trial of the efficacy and safety of interferon β-1a in treatment of severe COVID-19

E Davoudi-Monfared, H Rahmani… - Antimicrobial agents …, 2020 - Am Soc Microbiol
To the best of our knowledge, there is no published study on the use of interferon β-1a (IFN
β-1a) in the treatment of severe COVID-19. In this randomized clinical trial, the efficacy and …