BackgroundAlthough clozapine is the 'gold standard'for treatment-refractory schizophrenia,
meta-analyses of clozapine for this condition are lacking. AimsWe conducted a systematic …

Clozapine is the most effective antipsychotic for the 25% to 33% of people with
schizophrenia who are treatment resistant, but not all people achieve response. Using data …

Importance In treatment-resistant schizophrenia, clozapine is considered the standard
treatment. However, clozapine use has restrictions owing to its many adverse effects …

Originally published in February 2004. This guideline is more than 5 years old and has not
yet been updated to ensure that it reflects current knowledge and practice. In accordance …

Background Because of the debate about whether second-generation antipsychotic drugs
are better than first-generation antipsychotic drugs, we did a meta-analysis of randomised …

These updated guidelines are based on a first edition of the World Federation of Societies of
Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia …

Tardive dyskinesia (TD) risk with D2/serotonin receptor antagonists or D2 receptor partial
agonists (secondgeneration antipsychotics, SGAs) is considered significantly lower than …

Context Second-generation (atypical) antipsychotics (SGAs) are more expensive than first-
generation (typical) antipsychotics (FGAs) but are perceived to be more effective, with fewer …

Objective: When a schizophrenia patient has an inadequate response to treatment with an
antipsychotic drug, it is unclear what other antipsychotic to switch to and when to use …

Background Consensus panel recommendations regarding choice of an antipsychotic agent
for schizophrenia differ markedly, but most consider second-generation antipsychotics …