Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi

AC Mesías, NJ Garg, MP Zago - Frontiers in Cellular and Infection …, 2019 - frontiersin.org
The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …

Trypanothione metabolism as drug target for trypanosomatids

MD Piñeyro, D Arias, A Parodi-Talice… - Current …, 2021 - ingentaconnect.com
Chagas Disease, African sleeping sickness, and leishmaniasis are neglected diseases
caused by pathogenic trypanosomatid parasites, which have a considerable impact on …

Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum …

N Coetzee, S Sidoli, R Van Biljon, H Painter, M Llinás… - Scientific reports, 2017 - nature.com
Gene expression in Plasmodia integrates post-transcriptional regulation with epigenetic
marking of active genomic regions through histone post-translational modifications (PTMs) …

A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and …

DP Staneva, R Carloni, T Auchynnikava… - Genome …, 2021 - genome.cshlp.org
Nucleosomes composed of histones are the fundamental units around which DNA is
wrapped to form chromatin. Transcriptionally active euchromatin or repressive …

H2B.V demarcates divergent strand-switch regions, some tDNA loci, and genome compartments in Trypanosoma cruzi and affects parasite differentiation and host …

JN Rosón, MO Vitarelli, HM Costa-Silva… - PLoS …, 2022 - journals.plos.org
Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

Comparative proteomic analysis of lysine acetylation in trypanosomes

NS Moretti, I Cestari, A Anupama, K Stuart… - Journal of proteome …, 2018 - ACS Publications
Protein acetylation is a post-translational modification regulating diverse cellular processes.
By using proteomic approaches, we identified N-terminal and ε-lysine acetylated proteins in …

Improvements on the quantitative analysis of Trypanosoma cruzi histone post translational modifications: Study of changes in epigenetic marks through the parasite's …

LP de Lima, SB Poubel, ZF Yuan, JN Rosón… - Journal of …, 2020 - Elsevier
Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes,
although they are still decorated by post-translational modifications (PTMs). Here, we used a …

Post-translational Modifications of Trypanosoma cruzi Canonical and Variant Histones

GFA Picchi, V Zulkievicz, MA Krieger… - Journal of proteome …, 2017 - ACS Publications
Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …

Histone modifications and other facets of epigenetic regulation in trypanosomatids: leaving their mark

S Saha - MBio, 2020 - Am Soc Microbiol
Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular
processes, including transcription, replication, and repair. Vast arrays of modifications have …

Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases

A Parthasarathy, K Kalesh - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
Mass spectrometry-based proteomics enables accurate measurement of the modulations of
proteins on a large scale upon perturbation and facilitates the understanding of the …