The tetraspanin web represents a new concept of molecular interactions in the immune
system. Whereas most surface immune-modulating molecules involve receptor–ligand …

To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

Retinitis pigmentosa (RP) and allied diseases are heterogeneous clinically and genetically.
Here we summarize the retinal cell types involved in these diseases, the large number of …

Retinitis pigmentosa (RP) denotes a group of hereditary retinal dystrophies, characterized
by the early onset of night blindness followed by a progressive loss of the visual field. The …

Peripherin/rds is an integral membrane glycoprotein, mainly located in the rod and cone
outer segments. The relevance of this protein to photoreceptor outer segment morphology …

purpose. To examine the biochemical properties, cell expression, and localization of RS1,
the product of the gene responsible for X-linked juvenile retinoschisis. methods. Rs1h …

▪ Abstract The past decade has witnessed extraordinary progress in retinal disease gene
identification, the analysis of animal and tissue culture models of disease processes, and the …

ABCA4 is a member of the ABCA subfamily of ATP binding cassette (ABC) transporters that
is expressed in rod and cone photoreceptors of the vertebrate retina. ABCA4, also known as …

Mutations in the gene encoding ABCR (ABCA4), a photoreceptor-specific ATP-binding
cassette (ABC) transporter 1, 2, 3, 4, are responsible for autosomal recessive Stargardt …

PURPOSE: To measure the proportion of cases of retinitis pigmentosa (RP) caused by
mutations in the peripherin/RDS (RDS) and ROM1 genes. METHODS: The single-strand …