Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading
cause of cancer-related deaths among women worldwide. The main reasons for this poor …

Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …

Background Tumors contain a functional subpopulation of cells that exhibit stem cell
properties. These cells, named cancer stem cells (CSCs), play significant roles in the …

Triptolide possesses the trait of renal protection. Epithelial-mesenchymal transition (EMT) is
closely linked to the pathogenesis of diabetic kidney disease (DKD). MicroRNAs have …

Unlike most epithelial malignancies which metastasize hematogenously, metastasis of
epithelial ovarian cancer (EOC) occurs primarily via transcoelomic dissemination …

Objective This study aimed to investigate the antitumor effects and possible regulatory
mechanisms of sanguinarine in epithelial ovarian cancer. Material and methods The effects …

The incidence of nasopharyngeal carcinoma (NPC) exhibits significant variations across
different ethnic groups and geographical regions, with Southeast Asia and North Africa …

It was demonstrated that Sphingosine kinase 1 (SphK1) promotes tumor progression and
confers the malignancy phenotype of colorectal cancer by activating the focal adhesion …