A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Notch signalling is an evolutionarily highly conserved signalling mechanism governing
differentiation and regulating homeostasis in many tissues. In this review, we discuss recent …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common monogenic disorder of the cerebral …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

NOX5 (NADPH oxidase 5) is a homolog of the gp91phox subunit of the phagocyte NOX,
which generates reactive oxygen species. NOX5 is involved in sperm motility and vascular …

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control
cell fate in many developmental and adult tissue contexts. Notch signalling continues to be …

Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a monogenic disease caused by NOTCH3 mutations …

Aims Hypogonadism is associated with cardiovascular disease. However, the
cardiovascular impact of hypogonadism during development is unknown. Using …

Aims Diabetic nephropathy (DN) is the foremost basis of end-stage kidney failure implicating
endoplasmic reticulum (ER) stress and dysregulation of Rho kinase/Rock pathway …

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel …