Simple Summary Pediatric sarcomas, including Ewing sarcoma and osteosarcoma, were
first to be treated with an anticancer vaccine 100 years ago. This review moves on from a …

Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are
associated with many aggressive cancers with poor patient outcomes. Several FOs are now …

The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging
SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 …

Transcription factors regulate gene networks controlling normal hematopoiesis and are
frequently deregulated in acute myeloid leukemia (AML). Critical to our understanding of the …

Many cancers are characterized by gene fusions encoding oncogenic chimeric transcription
factors (TFs) such as EWS:: FLI1 in Ewing sarcoma (EwS). Here, we find that EWS:: FLI1 …

Fusion transcription factors generated by genomic translocations are common drivers of
several types of cancers including sarcomas and leukemias. Oncofusions of the FET (FUS …

Sarcomas are rare malignancies with over 100 distinct histological subtypes. Their rarity and
heterogeneity pose significant challenges to identifying effective therapies, and approved …

Transcription factor (TF) DNA-binding dynamics govern cell fate and identity. However, our
ability to pharmacologically control TF localization is limited. Here we leverage chemically …

Simple Summary Ewing Sarcoma treatment is traditionally based on chemotherapy, surgery,
and radiotherapy. Although these standard of care regimens are efficient at early disease …

Abstract Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive
malignant cancer caused by a chromosomal translocation t (11; 22)(p13; q12) that produces …