The family of cytokines signalling through the common receptor subunit gp130 comprises
interleukin (IL)-6, IL-11, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor …

The brain controls energy homeostasis and body weight by integrating various metabolic
signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral …

GH plays a pivotal role in regulating body growth and development, which is modulated by
sex steroids. A close interplay between estrogen and GH leads to attainment of …

The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate
cellular processes involved in cell growth, differentiation, and transformation through their …

Autosomal dominant polycystic kidney disease is characterized by cyst formation in the
kidney and other organs and results from mutations of PKD1 or PKD2. Previous studies …

In recent years, significant progress has been made in elucidating the signaling pathways
activated by the growth hormone (GH) receptor. An initiating event is probably the activation …

To expand our understanding of the role of Jak2 in cellular signaling, we used the yeast two-
hybrid system to identify Jak2-interacting proteins. One of the clones identified represents a …

Growth hormone (GH) has long been known to be the body's primary regulator of body
growth and a regulator of metabolism, yet the mechanisms by which GH regulates the …

Src homology 2 B adapter protein 1 (SH2B1) modulates signaling by a variety of ligands that
bind to receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin …

Rapid progress has been made recently in the definition of growth hormone (GH) receptor
signal transduction pathways. It is now apparent that many cytokines, including GH, share …