Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

Background. Since the advent of viral vector gene therapy in 1990s, cancer treatment with
viral vectors promised to revolutionize the field of oncology. Notably, viral vectors offer a …

A comprehensive translational cancer research approach focused on personalized and
precision medicine, and covering the entire cancer research–care–prevention continuum …

Cancer is among the major leading causes of mortality globally, and chemotherapy is
currently one of the most effective cancer therapies. Unfortunately, chemotherapy is …

Adenovirus (Ad)-based vectors have shown considerable promise for gene therapy.
However, Ad requires the coxsackievirus and adenovirus receptor (CAR) to enter cells …

Genetically modified cell sheet technology is emerging as a promising biomedical tool to
deliver therapeutic genes for regenerative medicine and tissue engineering. Virus-based …

Viral vectors play a pivotal role in the field of gene therapy, with several related drugs having
already gained clinical approval from the EMA and FDA. However, numerous viral gene …

Adenoviral vectors have been widely used as vaccine candidates or potential vaccine
candidates against infectious diseases due to the convenience of genome manipulation …

Current cancer therapeutics often insufficiently eradicate malignant cells due to the
surrounding dense tumor stroma. This multi-componential tissue consists of mainly cancer …

Lymphotoxin α (LTα) is a soluble factor produced by activated lymphocytes which is
cytotoxic to tumor cells. Although a promising candidate in cancer therapy, the application of …