[HTML][HTML] Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Z Ju, M Li, J Xu, DC Howell, Z Li, FE Chen - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Cyclooxygenases play a vital role in inflammation and are responsible for the production of
prostaglandins. Two cyclooxygenases are described, the constitutive cyclooxygenase-1 and …

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

HI Abd-Alla, D Souguir, MO Radwan - Archives of pharmacal research, 2021 - Springer
Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third
largest family of flowering plants. The genus Sophora comprises approximately 52 species …

Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …

D Luo, X Dai, H Tian, C Fan, H Xie, N Chen, J Wang… - Phytomedicine, 2023 - Elsevier
Background Novel compounds and more efficient treatment options are urgently needed for
the treatment of non-small cell lung cancer (NSCLC). The decoction of Sophora flavescens …

Research progress of natural matrine compounds and synthetic matrine derivatives

J Li, S Wei, D Marabada, Z Wang, Q Huang - Molecules, 2023 - mdpi.com
Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other
parts of the plant Sophora flavescens using an organic solvent. Matrine exhibits a variety of …

Quinolizidine-type alkaloids: chemodiversity, occurrence, and bioactivity

W Cely-Veloza, MJ Kato, E Coy-Barrera - ACS omega, 2023 - ACS Publications
Quinolizidine alkaloids (QAs) are nitrogen-containing compounds produced naturally as
specialized metabolites distributed in plants and animals (eg, frogs, sponges). The present …

Triterpenoids, steroids and other constituents from Euphorbia kansui and their anti-inflammatory and anti-tumor properties

JC Li, SY Li, JX Tang, D Liu, XY Feng, KR Rao… - Phytochemistry, 2022 - Elsevier
Six undescribed triterpenoids (euphokanols A− F), two undescribed C 21-steroidal
glycosides (euphokanosides A and B), together with fifty-four known compounds were …

Water-soluble matrine-type alkaloids with potential anti-neuroinflammatory activities from the seeds of Sophora alopecuroides

D Luo, Q Lin, JL Tan, HY Zhao, X Feng, NH Chen… - Bioorganic …, 2021 - Elsevier
A phytochemical investigation on the alkaloids from water-soluble part of Sophora
alopecuroides led to obtain forty matrine-type alkaloids (1–40) including eighteen new ones …

Structurally Diverse Matrine‐Based Alkaloids with Anti‐inflammatory Effects from Sophora alopecuroides

D Luo, NH Chen, WZ Wang, JH Zhang… - Chinese Journal of …, 2021 - Wiley Online Library
Main observation and conclusion A phytochemical investigation on the seeds of Sophora
alopecuroides led to obtaining fourteen structurally diverse matrine‐based alkaloids (1 …

Phytotoxic Activity of Alkaloids in the Desert Plant Sophora alopecuroides

L Lei, Y Zhao, K Shi, Y Liu, Y Hu, H Shao - Toxins, 2021 - mdpi.com
Sophora alopecuroides is known to produce relatively large amounts of alkaloids; however,
their ecological consequences remain unclear. In this study, we evaluated the allelopathic …

Biological activity of naturally derived naphthyridines

G Chabowska, E Barg, A Wójcicka - Molecules, 2021 - mdpi.com
Marine and terrestrial environments are rich sources of various bioactive substances, which
have been used by humans since prehistoric times. Nowadays, due to advances in chemical …