Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to
distinguish the unique molecular environment of fluorophores. FLIM measures the time a …

Cancer immunotherapy has revolutionized the way tumors are treated. Nevertheless,
efficient and robust testing platforms are still missing, including clinically relevant human ex …

Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …

Cancer immunotherapy is exploited for the treatment of disease by modulating the immune
system. Since the conventional in vivo animal and 2D in vitro models insufficiently …

The increasing number of publications on the subject shows that nanomedicine is an
attractive field for investigations aiming to considerably improve anticancer chemotherapy …

Hypoxia is characterized as insufficient oxygen delivery to tissues and cells in the body and
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …

Generation of human organoids from induced pluripotent stem cells (iPSCs) offers exciting
possibilities for developmental biology, disease modelling and cell therapy. Significant …

Abstract Background Multicellular Tumor Spheroids are frequently used to mimic the
regionalization of proliferation and the hypoxic environment within avascular tumors. Here …

Spheroids formed of mesenchymal stem cells (MSCs) exhibit increased cell survival and
trophic factor secretion compared with dissociated MSCs, making them therapeutically …

Oxygen imaging of biological cells and tissues is becoming increasingly important in cell
biology and in the pathophysiology of various hypoxia-related diseases. The optical oxygen …