The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …

Epigenetic alterations, along with genetic alterations, have long been regarded as the most
important mechanism participating in carcinogenesis. DNA methylation, histone …

This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …

Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly,
its dysregulation can contribute to the development of tumors. Epigenetic modifications, such …

Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …

N-Methylation of lysine and arginine residues has emerged as a major mechanism of
transcriptional regulation in eukaryotes. In humans, N ε-methyllysine residue demethylation …

DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …