Cell biology of T cell receptor expression and regulation
A Alcover, B Alarcón, V Di Bartolo - Annual review of …, 2018 - annualreviews.org
T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …
T-cell antigen receptor genes and T-cell recognition
MM Davis, PJ Bjorkman - Nature, 1988 - nature.com
The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …
Rapid and sensitive protein similarity searches
DJ Lipman, WR Pearson - Science, 1985 - science.org
An algorithm was developed which facilitates the search for similarities between newly
determined amino acid sequences and sequences already available in databases. Because …
determined amino acid sequences and sequences already available in databases. Because …
[图书][B] Fundamental immunology
WE Paul - 2012 - books.google.com
This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
AS Greenberg, D Avila, M Hughes, A Hughes… - nature, 1995 - nature.com
IMMUNOGLOBULIN and T-cell receptor (TCR) molecules are central to the adaptive
immune system. Sequence conservation, similarities in domain structure, and usage of …
immune system. Sequence conservation, similarities in domain structure, and usage of …
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
P Gantner, A Pagliuzza, M Pardons… - Nature …, 2020 - nature.com
Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of
proviral integration sites. However, the source of the proliferation of HIV-infected cells …
proviral integration sites. However, the source of the proliferation of HIV-infected cells …
Expression of chimeric receptor composed of immunoglobulin-derived V resions and T-cell receptor-derived C regions
Y Kuwana, Y Asakura, N Utsunomiya… - Biochemical and …, 1987 - Elsevier
Chimeric genes composed of immunoglobulin (Ig)-derived variable (V) regions and T-cell
receptor (TCR)-derived constant (C) regions were constructed. The VL and VH genes …
receptor (TCR)-derived constant (C) regions were constructed. The VL and VH genes …
The immunological synapse
ML Dustin - Cancer immunology research, 2014 - AACR
The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …
Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution
MA Saper, PJ Bjorkman, DC Wiley - Journal of molecular biology, 1991 - Elsevier
The three-dimensional structure of the human histocompatibility antigen HLA-A2 was
determined at 3.5 Å resolution by a combination of isomorphous replacement and iterative …
determined at 3.5 Å resolution by a combination of isomorphous replacement and iterative …
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
SM Hedrick, DI Cohen, EA Nielsen, MM Davis - Nature, 1984 - nature.com
Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B
lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region …
lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region …