T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …

An algorithm was developed which facilitates the search for similarities between newly
determined amino acid sequences and sequences already available in databases. Because …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

IMMUNOGLOBULIN and T-cell receptor (TCR) molecules are central to the adaptive
immune system. Sequence conservation, similarities in domain structure, and usage of …

Clonal expansions occur in the persistent HIV reservoir as shown by the duplication of
proviral integration sites. However, the source of the proliferation of HIV-infected cells …

Chimeric genes composed of immunoglobulin (Ig)-derived variable (V) regions and T-cell
receptor (TCR)-derived constant (C) regions were constructed. The VL and VH genes …

The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

The three-dimensional structure of the human histocompatibility antigen HLA-A2 was
determined at 3.5 Å resolution by a combination of isomorphous replacement and iterative …

Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B
lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region …