Recent advances in the structural mechanisms of DNA glycosylases
SC Brooks, S Adhikary, EH Rubinson… - Biochimica et Biophysica …, 2013 - Elsevier
DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …
MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles
AB Sjolund, AG Senejani, JB Sweasy - Mutation Research/Fundamental …, 2013 - Elsevier
The base excision repair system is vital to the repair of endogenous and exogenous DNA
damage. This pathway is initiated by one of several DNA glycosylases that recognizes and …
damage. This pathway is initiated by one of several DNA glycosylases that recognizes and …
[HTML][HTML] Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites
Thymine DNA glycosylase (TDG) excises T from G· T mispairs and is thought to initiate base
excision repair (BER) of deaminated 5-methylcytosine (mC). Recent studies show that TDG …
excision repair (BER) of deaminated 5-methylcytosine (mC). Recent studies show that TDG …
Chimeric d/l-DNA Probes of Base Excision Repair Enable Real-Time Monitoring of Thymine DNA Glycosylase Activity in Live Cells
W Zhong, JT Sczepanski - Journal of the American Chemical …, 2023 - ACS Publications
The base excision repair (BER) pathway is a frontline defender of genomic integrity and
plays a central role in epigenetic regulation through its involvement in the erasure of 5 …
plays a central role in epigenetic regulation through its involvement in the erasure of 5 …
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
H Hashimoto, S Hong, AS Bhagwat… - Nucleic acids …, 2012 - academic.oup.com
The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation
via the base excision repair pathway. TDG excises the mismatched base from G: X …
via the base excision repair pathway. TDG excises the mismatched base from G: X …
Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites
A Bellacosa, AC Drohat - DNA repair, 2015 - Elsevier
Cytosine methylation at CpG dinucleotides is a central component of epigenetic regulation
in vertebrates, and the base excision repair (BER) pathway is important for maintaining both …
in vertebrates, and the base excision repair (BER) pathway is important for maintaining both …
[HTML][HTML] Thermodynamics of nanocrystal–ligand binding through isothermal titration calorimetry
AB Greytak, SL Abiodun, JM Burrell, EN Cook… - Chemical …, 2022 - pubs.rsc.org
Manipulations of nanocrystal (NC) surfaces have propelled the applications of colloidal NCs
across various fields such as bioimaging, catalysis, electronics, and sensing applications. In …
across various fields such as bioimaging, catalysis, electronics, and sensing applications. In …
TET-TDG active DNA demethylation at CpG and non-CpG sites
JE DeNizio, BJ Dow, JC Serrano, U Ghanty… - Journal of molecular …, 2021 - Elsevier
In mammalian genomes, cytosine methylation occurs predominantly at CG (or CpG)
dinucleotide contexts. As part of dynamic epigenetic regulation, 5-methylcytosine (mC) can …
dinucleotide contexts. As part of dynamic epigenetic regulation, 5-methylcytosine (mC) can …
Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA
A Maiti, AZ Michelson, CJ Armwood… - Journal of the …, 2013 - ACS Publications
5-Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and
genome stability, and aberrant DNA methylation contributes to aging and cancer. Active …
genome stability, and aberrant DNA methylation contributes to aging and cancer. Active …
Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues
CT Coey, SS Malik, LS Pidugu, KM Varney… - Nucleic acids …, 2016 - academic.oup.com
Abstract Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …