Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Abstract Treatment resistant schizophrenia (TRS) refers to the significant proportion of
schizophrenia patients who continue to have symptoms and poor outcomes despite …

There has been an increasing trend towards the use of complexity analysis in quantifying
neural activity measured by electroencephalography (EEG) signals. On top of revealing …

Negative symptoms in schizophrenia may be classified as primary or secondary. Primary
negative symptoms are thought to be intrinsic to schizophrenia, while secondary negative …

The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that
is not committed to protein synthesis and includes compounds active in the nervous and …

To test the hypothesis that the ability to actively represent and maintain context information is
a central function of working memory and that a disturbance in this function contributes to …

Several lines of evidence support the notion that a substantial reorganization of cortical
connections, involving a programmed synaptic pruning, takes place during adolescence in …

Background Negative symptoms in schizophrenia concern a clinically relevant reduction of
goal-directed behavior that strongly and negatively impacts daily functioning. Existing …

Background: Schizophrenic patients show various deficits in cognitive functions that have
been difficult to understand in terms of a common unifying hypothesis. Previously described …

Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased
expression of the immune gene C4 has been linked to a greater risk of developing …