Abstract Cytochrome P450 (P450) 2E1 is the major P450 enzyme involved in ethanol
metabolism. That role is shared with two other enzymes that oxidize ethanol, alcohol …

Organic solvents are common chemicals used in industry throughout the world, however,
there is evidence for adverse health effects from exposure to these compounds …

In the present study, the combined toxic effect of microplastics and their additives (five) on
aquatic organisms (zebrafish) was studied using full factorial design method, molecular …

Human health and well-being are intricately linked to environmental quality. Environmental
exposures can have lifelong consequences. In particular, exposures during the vulnerable …

A systematic review and meta-analysis were conducted, aiming to establish a scientifically
grounded understanding of trichloroethylene (TCE)-induced hepatotoxicity. Relevant studies …

Acrylamide (AA) is classified as a probable human carcinogen and is ubiquitous in foods
processed at high temperatures. The carcinogenicity of AA has been attributed to its active …

Epidemiological evidence indicates that exposure to halogenated polycyclic aromatic
hydrocarbons (HPAHs) is associated with many adverse effects. However, the mechanisms …

Rationale: CYPs (cytochrome p450) are critically involved in the metabolism of xenobiotics
and toxins. Given that pulmonary hypertension is strongly associated with environmental …

The evaluation of exposure to multiple contaminants in a mixture presents a number of
challenges. For example, the characterization of chemical metabolism in a mixture setting …

Background: Interindividual variability in susceptibility remains poorly characterized for
environmental chemicals such as tetrachloroethylene (PERC). Development of population …