Cortical bone porosity: what is it, why is it important, and how can we detect it?

DML Cooper, CE Kawalilak, K Harrison… - Current osteoporosis …, 2016 - Springer
There is growing recognition of the role of micro-architecture in osteoporotic bone loss and
fragility. This trend has been driven by advances in imaging technology, which have …

[PDF][PDF] Towards novel measurements of remodeling activity in cortical bone: implications for osteoporosis and related pharmaceutical treatments

LL Loundagin, DML Cooper - Eur. Cell Mater, 2022 - ecmjournal.org
Bone remodelling is performed by basic multicellular units (BMUs) that resorb and
subsequently form discrete packets of bone tissue. Normally, the resorption and formation …

Coupling of bone resorption and formation in real time: new knowledge gained from human Haversian BMUs

NE Lassen, TL Andersen, GG Pløen… - Journal of Bone and …, 2017 - academic.oup.com
It is well known that bone remodeling starts with a resorption event and ends with bone
formation. However, what happens in between and how resorption and formation are …

[HTML][HTML] Osteocyte-directed bone demineralization along canaliculi

N Nango, S Kubota, T Hasegawa, W Yashiro… - Bone, 2016 - Elsevier
The mammalian skeleton stores calcium and phosphate ions in bone matrix. Osteocytes in
osteocyte lacunae extend numerous dendrites into canaliculi less than a micron in diameter …

Three‐dimensional reconstruction of Haversian systems in human cortical bone using synchrotron radiation‐based micro‐CT: morphology and quantification of …

IS Maggiano, CM Maggiano, JG Clement… - Journal of …, 2016 - Wiley Online Library
This study uses synchrotron radiation‐based micro‐computed tomography (CT) scans to
reconstruct three‐dimensional networks of Haversian systems in human cortical bone in …

Cortical bone porosity in rabbit models of osteoporosis

KD Harrison, BD Hiebert, A Panahifar… - Journal of Bone and …, 2020 - academic.oup.com
Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and
is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis …

Tomographic in vivo microscopy for the study of lung physiology at the alveolar level

G Lovric, R Mokso, F Arcadu, I Vogiatzis Oikonomidis… - Scientific reports, 2017 - nature.com
Lungs represent the essential part of the mammalian respiratory system, which is reflected in
the fact that lung failure still is one of the leading causes of morbidity and mortality …

[HTML][HTML] Daily administration of parathyroid hormone slows the progression of basic multicellular units in the cortical bone of the rabbit distal tibia

DML Cooper, KD Harrison, BD Hiebert, GA King… - Bone, 2023 - Elsevier
Abstract Basic Multicellular Units (BMUs) conduct bone remodeling, a critical process of
tissue turnover which, if imbalanced, can lead to disease, including osteoporosis …

Factors influencing real time internal structural visualization and dynamic process monitoring in plants using synchrotron-based phase contrast X-ray imaging

C Karunakaran, R Lahlali, N Zhu, AM Webb… - Scientific Reports, 2015 - nature.com
Minimally invasive investigation of plant parts (root, stem, leaves and flower) has good
potential to elucidate the dynamics of plant growth, morphology, physiology and root …

Modalities for visualization of cortical bone remodeling: the past, present, and future

KD Harrison, DML Cooper - Frontiers in endocrinology, 2015 - frontiersin.org
Bone's ability to respond to load-related phenomena and repair microdamage is achieved
through the remodeling process, which renews bone by activating groups of cells known as …