Advances in TRP channel drug discovery: from target validation to clinical studies
AP Koivisto, MG Belvisi, R Gaudet… - Nature reviews Drug …, 2022 - nature.com
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …
A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain
Microglia, resident macrophages of the CNS, are essential to brain development,
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
homeostasis, and disease. Microglial activation and proliferation are hallmarks of many CNS …
Unravelling the interplay between extracellular acidosis and immune cells
F Erra Díaz, E Dantas, J Geffner - Mediators of inflammation, 2018 - Wiley Online Library
The development of an acidic tissue environment is a hallmark of a variety of inflammatory
processes and solid tumors. However, little attention has been paid so far to analyze the …
processes and solid tumors. However, little attention has been paid so far to analyze the …
Involvement of neural transient receptor potential channels in peripheral inflammation
HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
channels that act as polymodal sensors in many tissues throughout mammalian organisms …
Transient receptor potential channels in the vasculature
S Earley, JE Brayden - Physiological reviews, 2015 - journals.physiology.org
The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …
Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) …
FA Iannotti, CL Hill, A Leo, A Alhusaini… - ACS chemical …, 2014 - ACS Publications
Epilepsy is the most common neurological disorder, with over 50 million people worldwide
affected. Recent evidence suggests that the transient receptor potential cation channel …
affected. Recent evidence suggests that the transient receptor potential cation channel …
Transient receptor potential (TRP) channels: a clinical perspective
Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
Unravelling the mystery of capsaicin: a tool to understand and treat pain
A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …
physiological systems, with an emphasis on pain research but also including functions such …