Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

A wide variety of human diseases have been modelled in zebrafish, including various types
of cancer, cardiovascular diseases and neurodegenerative diseases like Alzheimer's and …

The degeneration of nigral dopaminergic neurons is considered the hallmark of Parkinson's
disease (PD), and it is triggered by different factors, including mitochondrial dysfunction …

Parkinson's disease (PD) is a neurodegenerative disorder primarily known for typical motor
features that arise due to the loss of dopaminergic neurons in the substantia nigra. However …

Kainate receptors (KARs) constitute a family of ionotropic glutamate receptors (iGluRs) with
distinct physiological roles in synapses and neuronal circuits. Despite structural and …

Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission
and are implicated in various neurological disorders. In this review, we discuss the role of …

Neural activity is finely tuned to produce normal behaviors, and disruptions in activity likely
occur early in the course of many neurodegenerative diseases. However, how neural activity …

Parkinson's disease (PD) is the second major progressive neurodegenerative disease,
which critically impacts patients' quality of life. Based on genetics, animal models of genetic …

The neuroprotective effects of Er-Zhi-Wan (EZW), a well-known traditional Chinese
formulation, in MPTP-induced Parkinson's disease (PD) models are poorly understood and …

Mutations in the PRKN gene encoding the protein parkin cause autosomal recessive
juvenile parkinsonism (ARJP). Harnessing this mutation to create an early-onset Parkinson's …