Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury
to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm …

Neural respiratory drive, ie, the activity of respiratory centres controlling breathing, is an
overlooked physiologic variable which affects the pathophysiology and the clinical outcome …

Rationale: Monitoring and controlling respiratory drive and effort may help to minimize lung
and diaphragm injury. Airway occlusion pressure (P0. 1) is a noninvasive measure of …

This narrative review explores the physiology and evidence-based management of patients
with severe acute respiratory distress syndrome (ARDS) and refractory hypoxemia, with a …

Sleep is controlled by two major regulatory systems: a circadian system that drives 24-h
periodicity (Process C), and a homeostatic system (Process S) that ensures adequate …

Background Mechanical ventilation is common in critically ill patients. This life-saving
treatment can cause complications and is also associated with long-term sequelae. Patient …

Delirium is a syndrome characterized by acute brain failure resulting in neurocognitive
disturbances affecting attention, awareness, and cognition. It is highly prevalent among …

OBJECTIVES: Patient-ventilator asynchrony is often observed during mechanical ventilation
and is associated with higher mortality. We hypothesized that patient-ventilator asynchrony …

Acute respiratory distress syndrome (ARDS) is a leading cause of disability and mortality
worldwide, and while no specific etiologic interventions have been shown to improve …

The estimation of pleural pressure with esophageal manometry has been used for decades,
and it has been a fertile area of physiology research in healthy subject as well as during …