Electrospinning provides a versatile technique for the preparation of matrices with
micro/nanoscopic fibers. The non-woven polymer materials produced by electrospinning …

Over the last years, chitosan has demonstrated unparalleled characteristics for regenerative
medicine applications. Beside excellent antimicrobial and wound healing properties, this …

The treatment of long-gap (> 10 mm) peripheral nerve injury (PNI) and spinal cord injury
(SCI) remains a continuous challenge due to limited native tissue regeneration capabilities …

Regeneration and functional recovery of peripheral nerves remain formidable due to the
inefficient physical and chemical cues in the available nerve guidance conduits (NGCs) …

Nerve growth strongly relies on multiple chemical and physical signals throughout
development and regeneration. Currently, a cure for injured neuronal tissue is an unmet …

There have been extensive studies on the application of topography in the field of tissue
repair. A common feature of these studies is that the existence of topological structures in …

We report a simple method based upon coaxial electrospinning for the fabrication of aligned
microfibers engraved with nanoscale grooves to promote neurite outgrowth and cell …

Both of the surface topographical features and distribution of biochemical cues can influence
the cell-substrate interactions and thereby tissue regeneration in vivo. However, they have …

Regenerative medicine is continuously facing new challenges and it is searching for new
biocompatible, green/natural polymer materials, possibly biodegradable and non …

Several studies suggest that topographical patterns influence nerve cell fate. Efforts have
been made to improve nerve cell functionality through this approach, focusing on …