The Arp2/3 regulatory system and its deregulation in cancer

N Molinie, A Gautreau - Physiological reviews, 2018 - journals.physiology.org
The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Endocytosis and signaling: cell logistics shape the eukaryotic cell plan

S Sigismund, S Confalonieri, A Ciliberto… - Physiological …, 2012 - journals.physiology.org
Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Extensive identification and analysis of conserved small ORFs in animals

SD Mackowiak, H Zauber, C Bielow, D Thiel, K Kutz… - Genome biology, 2015 - Springer
Background There is increasing evidence that transcripts or transcript regions annotated as
non-coding can harbor functional short open reading frames (sORFs). Loss-of-function …

Recognition of the polycistronic nature of human genes is critical to understanding the genotype-phenotype relationship

MA Brunet, SA Levesque, DJ Hunting… - Genome …, 2018 - genome.cshlp.org
Technological advances promise unprecedented opportunities for whole exome sequencing
and proteomic analyses of populations. Currently, data from genome and exome …

Targeting the WASF3 complex to suppress metastasis

AJ Limaye, MK Whittaker, GN Bendzunas… - Pharmacological …, 2022 - Elsevier
Wiskott-Aldrich syndrome protein family members (WASF) regulate the dynamics of the actin
cytoskeleton, which plays an instrumental role in cancer metastasis and invasion …

The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium

WJ Spencer, NF Schneider, TR Lewis… - Proceedings of the …, 2023 - National Acad Sciences
The photoreceptor outer segment is a modified cilium filled with hundreds of flattened “disc”
membranes responsible for efficient light capture. To maintain photoreceptor health and …

Loss of Scar/WAVE complex promotes N-WASP-and FAK-dependent invasion

H Tang, A Li, J Bi, DM Veltman, T Zech, HJ Spence… - Current Biology, 2013 - cell.com
Summary Background The Scar/WAVE regulatory complex (WRC) drives lamellipodia
assembly via the Arp2/3 complex, whereas the Arp2/3 activator N-WASP is not essential for …

The role of WAVE2 signaling in cancer

PS Rana, A Alkrekshi, W Wang, V Markovic… - Biomedicines, 2021 - mdpi.com
The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous
protein (WAVE)—WAVE1, WAVE2 and WAVE3 regulate rapid reorganization of cortical actin …

Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells

A Allen, D Gau, P Francoeur, J Sturm, Y Wang… - Journal of Biological …, 2020 - ASBMB
Clear-cell renal cell carcinoma (ccRCC), the most common subtype of renal cancer, has a
poor clinical outcome. A hallmark of ccRCC is genetic loss-of-function of VHL (von Hippel …

HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells

T Sharif, E Martell, C Dai, MS Ghassemi-Rad… - Autophagy, 2019 - Taylor & Francis
Cancer stem-like cells (CSCs), a small population of pluripotent cells residing within
heterogeneous tumor mass, remain highly resistant to various chemotherapies as compared …