The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …

Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures
that only occurs under pathological conditions. In the present paper, we summarize the …

Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

The microbiome is defined as the collective genomes of the microbes (composed of
bacteria, bacteriophage, fungi, protozoa, and viruses) that colonize the human body, and …

Spreading depolarizations are characterized by abrupt, near-complete breakdown of the
transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate …

Purpose.: To investigate ocular blood flow and visual function in the Ins2 Akita diabetic
retinopathy mouse model at early and late time points after onset of hyperglycemia …

Significance: The brain has high energetic requirements and is therefore highly dependent
on adequate cerebral blood supply. To compensate for dangerous fluctuations in cerebral …

Purpose To explore the capability of amide proton transfer (APT) imaging in the detection of
hemorrhagic and ischemic strokes using preclinical rat models. Methods The rat …

Pharmacological and device-induced reperfusion therapies have demonstrated increasingly
positive outcomes regarding both reperfusion efficacy and 90-day functional outcomes after …