Mouse hybrid genome mediates diverse brain phenotypes with the specificity of reciprocal crosses
MY Chou, D Appan, KW Chang, CH Chou… - The FASEB …, 2022 - Wiley Online Library
Hybrid species have more genetic diversity than their parents. However, the impact of the
hybrid genome of reciprocal crosses on brain function remains largely unknown. We …
hybrid genome of reciprocal crosses on brain function remains largely unknown. We …
UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death
M Koizumi, H Eto, M Saeki, M Seki… - The FASEB …, 2022 - Wiley Online Library
Recent studies have demonstrated that epigenetic modifications are deeply involved in
neurogenesis; however, the precise mechanisms remain largely unknown. To determine the …
neurogenesis; however, the precise mechanisms remain largely unknown. To determine the …
[HTML][HTML] A simple method for gene expression in endo-and ectodermal cells in mouse embryos before neural tube closure
Y Maeda, J Ding, M Saeki, N Kuwayama, Y Kishi - Developmental Biology, 2024 - Elsevier
The lack of a widely accessible method for expressing genes of interest in wild-type embryos
is a fundamental obstacle to understanding genetic regulation during embryonic …
is a fundamental obstacle to understanding genetic regulation during embryonic …
[HTML][HTML] Protocol for differential multi-omic analyses of distinct cell types in the mouse cerebral cortex
DP Meka, M Richter, T Rücker, H Voss, A Rissiek… - STAR protocols, 2024 - Elsevier
Here, we present a protocol for differential multi-omic analyses of distinct cell types in the
developing mouse cerebral cortex. We describe steps for in utero electroporation …
developing mouse cerebral cortex. We describe steps for in utero electroporation …
Propagation of neuronal micronuclei regulates microglial states
Microglia, resident immune cells in the central nervous system, undergo morphological and
functional changes in response to signals from the local environment and mature into …
functional changes in response to signals from the local environment and mature into …
[HTML][HTML] Analysis of histone modifications in mouse neocortical neural progenitor-stem cells at various developmental stages
M Tsuboi, Y Gotoh - STAR protocols, 2021 - Elsevier
Dynamic changes in histone modifications mediated by Polycomb group proteins can be
indicative of the transition of gene repression mode during development. Here, we present …
indicative of the transition of gene repression mode during development. Here, we present …
In utero gene transfer system for embryos before neural tube closure reveals a role for Hmga2 in the onset of neurogenesis
N Kuwayama, Y Kishi, Y Maeda, Y Nishiumi, Y Suzuki… - bioRxiv, 2020 - biorxiv.org
During the early stage of mammalian neural development, neuroepithelial cells (NECs)
proliferate and increase their pool size before switching their fate to become neurogenic …
proliferate and increase their pool size before switching their fate to become neurogenic …