Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal causes of cancer-
related death worldwide. The treatment of HCC remains challenging and is largely …

As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

Epidemiological data indicate a constant worldwide increase in cancer mortality, although
the age of onset is increasing. Recent accumulation of genomic data on human cancer via …

Cancer cells, relative to normal cells, demonstrate significant alterations in metabolism that
are proposed to result in increased steady-state levels of mitochondrial-derived reactive …

Hepatocarcinogenesis is a slow process during which genomic changes progressively alter
the hepatocellular phenotype to produce cellular intermediates that evolve into …

The current concept of radiobiology posits that damage to the DNA in the cell nucleus is the
primary cause for the detrimental effects of radiation. However, emerging experimental …

Reactive oxygen species (ROS) are induced through a variety of endogenous and
exogenous sources. Overwhelming of antioxidant and DNA repair mechanisms in the cell by …

Oncogene‐induced hyper‐proliferation in cancer cells is accompanied by the onset of
different stresses, including DNA‐replication stress, metabolic stress and oxidative stress …

The liver is an important metabolic and detoxification organ and hence demands a large
amount of energy, which is mainly produced by the mitochondria. Liver tissues of patients …

Somatic mitochondrial DNA (mtDNA) mutations have been increasingly observed in primary
human cancers. As each cell contains many mitochondria with multiple copies of mtDNA, it …