Objectives Patients with liver cirrhosis are prone to develop severe bacterial infections.
Pharmacokinetics (PK) of antibiotics in cirrhosis are potentially affected by impaired …

Bacterial infections are common events that significantly impact the clinical course of
patients with cirrhosis. As in the general population, infections caused by multi-drug …

(1) Background: Acute-on-chronic liver failure (ACLF) is a severe, rapidly progressing
disease in patients with liver cirrhosis. Meropenem is crucial for treating severe infections …

Cirrhosis is an immune dysfunction state, and as such, patients with cirrhosis are susceptible
to bacterial, fungal, and viral infections. Because of infection, these patients have a …

This study investigated tigecycline exposure in critically ill patients from a population
pharmacokinetic perspective to support rational dosing in intensive care unit (ICU) patients …

Antimicrobial resistance is a growing global health problem, and it is especially relevant
among liver transplant recipients where infections, particularly when caused by …

Effective antimicrobial therapy remains paramount to successful treatment of patients with
critical illness, such as pneumonia and sepsis. Unfortunately, critically ill patients often …

Introduction: Biapenem is a carbapenem antibiotic widely used in Asia, can be used for the
treatment of adults and children with infections due to susceptible bacteria. Although …

Aims Theophylline clearance is known to be reduced in patients with chronic liver diseases
(CLDs) such as chronic hepatitis (CH) and liver cirrhosis (LC). The Child–Pugh (CP) score is …

Background The increase in prevalence of liver disease globally will lead to a substantial
incremental burden on intensive care requirements. While liver transplantation offers a …