Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Astrocytes intimately interact with synapses, both morphologically and, as evidenced in the
past 20 years, at the functional level. Ultrathin astrocytic processes contact and sometimes …

Efficient neuronal signaling in the central nervous system strictly depends on a well‐
balanced microenvironment around glial cells, synapses, and axons. Unique features of the …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes
after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and …

Astrocytes are key homeostatic and defensive cells of the central nervous system (CNS).
They undertake numerous functions during development and in adulthood to support and …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Extracellular nucleotides, and ATP in particular, are cellular signal substances involved in
the control of numerous (patho) physiological mechanisms. They provoke nucleotide …

Inflammasomes are a group of supramolecular complexes primarily comprise a sensor,
adaptor protein and an effector. Among them, canonical inflammasomes are assembled by …

The central nervous system (CNS) is composed of a highly heterogeneous population of
cells. Dynamic interactions between different compartments (neuronal, glial, and vascular …