Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

The introduction of the “maximum tolerated dose” in usual treatment protocols (and its
concomitant overt toxicity) made necessary the imposition of rest periods between cycles of …

Background: We evaluated bevacizumab with metronomic etoposide among recurrent
malignant glioma patients in a phase 2, open-label trial. Methods: A total of 59 patients …

Metastasis suppressor proteins regulate multiple steps in the metastatic cascade, including
cancer cell invasion, survival in the vascular and lymphatic circulation, and colonization of …

Given that cancer is one of the main causes of death worldwide, many efforts have been
directed toward discovering new treatments and approaches to cure or control this group of …

Since angiogenesis is critical for tumor growth and metastasis, anti-angiogenic treatment is
a highly promising therapeutic approach. Thus, for over last couple of decades, there has …

Tumor-infiltrating T cell rescue by programmed cell death receptor-1 (PD-1)/PD-1 ligand-1
(PD-L1) immune checkpoint blockade is a recommended treatment for malignant diseases …

Immune‑checkpoint blockade by Nivolumab, a human monoclonal antibody to programmed
cell death receptor‑1, is an emerging treatment for metastatic non‑small cell lung cancer …

The mPEBev is an anticancer regimen which combines a chemotherapy doublet, based on
cisplatin and oral etoposide (mPE), with bevacizumab (mPEBev), a mAb targeting the …