The association of female and male infertility with telomere length

E Vasilopoulos, P Fragkiadaki… - International …, 2019 - spandidos-publications.com
Telomere length (TL) has long been associated with aging, as telomeres serve as protective
caps of chromosomes, and are thus deeply involved in the preservation of genome integrity …

Raman Microspectroscopy evidence of microplastics in human semen

L Montano, E Giorgini, V Notarstefano, T Notari… - Science of the Total …, 2023 - Elsevier
The presence of microplastics (MPs) in human fluids and organs is a great concern, since,
as highlighted by recent studies on animal models, they could cause alterations of several …

Oxidative stress and reproductive function: Sperm telomeres, oxidative stress, and infertility

A Moazamian, P Gharagozloo, RJ Aitken… - …, 2022 - rep.bioscientifica.com
In brief Oxidative stress is recognized as an underlying driving factor of both telomere
dysfunction and human subfertility/infertility. This review briefly reassesses telomere integrity …

Discovery of the involvement in DNA oxidative damage of human sperm nuclear basic proteins of healthy young men living in polluted areas

G Lettieri, G D'Agostino, E Mele, C Cardito… - International Journal of …, 2020 - mdpi.com
DNA oxidative damage is one of the main concerns being implicated in severe cell
alterations, promoting different types of human disorders and diseases. For their …

Molecular alterations in spermatozoa of a family case living in the land of fires—a first look at possible transgenerational effects of pollutants

G Lettieri, F Marra, C Moriello, M Prisco… - International Journal of …, 2020 - mdpi.com
In our previous work, we reported alterations in protamines/histones ratio, in DNA binding of
these proteins and their involvement in DNA oxidative damage in 84% of the young men …

Functional association between telomeres, oxidation and mitochondria

E Moustakli, A Zikopoulos, P Sakaloglou… - … in Reproductive Health, 2023 - frontiersin.org
Prior research has substantiated the vital role of telomeres in human fertility. Telomeres are
prerequisites for maintaining the integrity of chromosomes by preventing the loss of genetic …

Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells

G Ferrero, R Festa, L Follia, G Lettieri, S Tarallo… - Molecular …, 2024 - Springer
Background Molecular techniques can complement conventional spermiogram analyses to
provide new information on the fertilizing potential of spermatozoa and to identify early …

Molecular alterations and severe abnormalities in spermatozoa of young men living in the “Valley of Sacco River”(Latium, Italy): a preliminary study

P Perrone, G Lettieri, C Marinaro, V Longo… - International Journal of …, 2022 - mdpi.com
The Valley of Sacco River (VSR)(Latium, Italy) is an area with large-scale industrial chemical
production that has led over time to significant contamination of soil and groundwater with …

Telomere length, a new biomarker of male (in) fertility? A systematic review of the literature

AJ Fattet, M Chaillot, I Koscinski - Genes, 2023 - mdpi.com
Male factors are suspected in around half cases of infertility, of which up to 40% are
diagnosed as idiopathic. In the context of a continuously increased resort to ART and …

Sperm DNA fragmentation: An early and reliable marker of air pollution

L Bosco, T Notari, G Ruvolo, MC Roccheri… - Environmental …, 2018 - Elsevier
Environmental factors could have a key role in the continuous and remarkable decline of
sperm quality observed in the last decades. This study compared the seminal parameters …