Pathogenesis of pneumonia and acute lung injury

ME Long, RK Mallampalli, JC Horowitz - Clinical Science, 2022 - portlandpress.com
Pneumonia and its sequelae, acute lung injury, present unique challenges for pulmonary
and critical care healthcare professionals, and these challenges have recently garnered …

Biological phenotyping in sepsis and acute respiratory distress syndrome

P Sinha, NJ Meyer, CS Calfee - Annual review of medicine, 2023 - annualreviews.org
Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …

Phenotypes and personalized medicine in the acute respiratory distress syndrome

MA Matthay, YM Arabi, ER Siegel, LB Ware… - Intensive care …, 2020 - Springer
Although the acute respiratory distress syndrome (ARDS) is well defined by the
development of acute hypoxemia, bilateral infiltrates and non-cardiogenic pulmonary …

Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

From sepsis to acute respiratory distress syndrome (ARDS): emerging preventive strategies based on molecular and genetic researches

Q Hu, C Hao, S Tang - Bioscience Reports, 2020 - portlandpress.com
A healthy body activates the immune response to target invading pathogens (ie viruses,
bacteria, fungi, and parasites) and avoid further systemic infection. The activation of …

[HTML][HTML] Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation

JH Madenspacher, ED Morrell, KM Gowdy… - JCI insight, 2020 - ncbi.nlm.nih.gov
Alveolar macrophages (AM) play a central role in initiation and resolution of lung
inflammation, but the integration of these opposing core functions is poorly understood. AM …

Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research

LDJ Bos, A Artigas, JM Constantin… - European …, 2021 - Eur Respiratory Soc
Acute respiratory distress syndrome (ARDS) is a devastating critical illness that can be
triggered by a wide range of insults and remains associated with a high mortality of around …

Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies

M Shankar-Hari, T Calandra, MP Soares… - The Lancet …, 2024 - thelancet.com
Sepsis is a common and deadly condition. Within the current model of sepsis
immunobiology, the framing of dysregulated host immune responses into proinflammatory …

In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression …

L Artigas, M Coma, P Matos-Filipe, J Aguirre-Plans… - PLoS …, 2020 - journals.plos.org
From January 2020, COVID-19 is spreading around the world producing serious respiratory
symptoms in infected patients that in some cases can be complicated by the severe acute …

Pathophysiology of the acute respiratory distress syndrome: insights from clinical studies

P Sinha, LD Bos - Critical Care Clinics, 2021 - criticalcare.theclinics.com
Acute respiratory distress syndrome (ARDS) is a frequently encountered clinical syndrome
associated with unacceptably high morbidity and mortality. 1 Since its first description in …