Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Classical and non-classical monocytes, and the macrophages and monocyte-derived
dendritic cells they produce, play key roles in host defense against pathogens, immune …

Cardiovascular diseases (CVDs) incidence is becoming higher. This fact is promoted by
metabolic disorders such as obesity, and aging. Atherosclerosis is the underlying cause of …

Most cancers emerge in the elderly, including lung cancer and mesothelioma, yet the elderly
remain an underrepresented population in pre-clinical cancer studies and clinical trials. The …

It is clear that the gastrointestinal tract influences metabolism and immune function. Most
studies to date have used male test subjects, with a focus on effects of obesity and dietary …

Aging is associated with chronic, low-grade inflammation that adversely affects physiological
function. The liver regulates systemic inflammation; it is a source of cytokine production and …

The heavy metal cadmium (Cd) is known to modulate immunity and cause osteoporosis.
However, how Cd influences on hematopoiesis remain largely unknown. Herein, we show …

Hair follicle stem cells are extensively reprogrammed by the aging process, manifesting as
diminished self-renewal and delayed responsiveness to activating cues, orchestrated by …

Aging is associated with significant changes in hematopoiesis that include a shift from
lymphopoiesis to myelopoiesis and an expansion of phenotypic hematopoietic stem cells …

Background Sepsis survivors exhibit immune dysregulation that contributes to poor long-
term outcomes. Phenotypic and functional alterations within the myeloid compartment are …