AMPK—sensing energy while talking to other signaling pathways
DG Hardie - Cell metabolism, 2014 - cell.com
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …
Origin and diversity of plant receptor-like kinases
Because of their high level of diversity and complex evolutionary histories, most studies on
plant receptor-like kinase subfamilies have focused on their kinase domains. With the large …
plant receptor-like kinase subfamilies have focused on their kinase domains. With the large …
[HTML][HTML] Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
HSP90 is a molecular chaperone that associates with numerous substrate proteins called
clients. It plays many important roles in human biology and medicine, but determinants of …
clients. It plays many important roles in human biology and medicine, but determinants of …
Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis
V Joukov, A De Nicolo - Science signaling, 2018 - science.org
Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …
Diversity, classification and function of the plant protein kinase superfamily
MD Lehti-Shiu, SH Shiu - Philosophical Transactions of …, 2012 - royalsocietypublishing.org
Eukaryotic protein kinases belong to a large superfamily with hundreds to thousands of
copies and are components of essentially all cellular functions. The goals of this study are to …
copies and are components of essentially all cellular functions. The goals of this study are to …
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases
JM Arencibia, D Pastor-Flores, AF Bauer… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
Day of the dead: pseudokinases and pseudophosphatases in physiology and disease
Pseudophosphatases and pseudokinases are increasingly viewed as integral elements of
signaling pathways, and there is mounting evidence that they have frequently retained the …
signaling pathways, and there is mounting evidence that they have frequently retained the …
Exaptive evolution of target of rapamycin signaling in multicellular eukaryotes
JO Brunkard - Developmental Cell, 2020 - cell.com
Target of rapamycin (TOR) is a protein kinase that coordinates metabolism with nutrient and
energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have …
energy availability in eukaryotes. TOR and its primary interactors, RAPTOR and LST8, have …
Anti-Giardia Drug Discovery: Current Status and Gut Feelings
Giardia parasites are ubiquitous protozoans of global importance that impact a wide range
of animals including humans. They are the most common enteric pathogen of cats and dogs …
of animals including humans. They are the most common enteric pathogen of cats and dogs …
Kinases and pseudokinases: lessons from RAF
Protein kinases are thought to mediate their biological effects through their catalytic activity.
The large number of pseudokinases in the kinome and an increasing appreciation that they …
The large number of pseudokinases in the kinome and an increasing appreciation that they …