Epigenetic protein families: a new frontier for drug discovery
Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …
establishes normal cellular phenotypes but also contributes to human diseases. At the …
Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota
M Wu, Q Luo, R Nie, X Yang, Z Tang… - Critical reviews in food …, 2021 - Taylor & Francis
Naturally occurring compounds polyphenols are secondary metabolites of plants, comprised
several categories, namely, flavonoids, phenolic acids, lignans and stilbenes. The biological …
several categories, namely, flavonoids, phenolic acids, lignans and stilbenes. The biological …
[HTML][HTML] Role of acetylation in doxorubicin-induced cardiotoxicity
D Li, Y Yang, S Wang, X He, M Liu, B Bai, C Tian… - Redox Biology, 2021 - Elsevier
As a potent chemotherapeutic agent, doxorubicin (DOX) is widely used for the treatment of a
variety of cancers However, its clinical utility is limited by dose-dependent cardiotoxicity, and …
variety of cancers However, its clinical utility is limited by dose-dependent cardiotoxicity, and …
[HTML][HTML] Histone acetyltransferases: challenges in targeting bi-substrate enzymes
H Wapenaar, FJ Dekker - Clinical epigenetics, 2016 - Springer
Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …
Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes
Y Li, D Shin, SH Kwon - The FEBS journal, 2013 - Wiley Online Library
Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …
regulates many important biological processes via the formation of complexes with its …
[HTML][HTML] SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity
H Yang, W Zhang, H Pan, HG Feldser, E Lainez… - 2012 - journals.plos.org
Chronic inflammation is a major contributing factor in the pathogenesis of many age-
associated diseases. One central protein that regulates inflammation is NF-κB, the activity of …
associated diseases. One central protein that regulates inflammation is NF-κB, the activity of …
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …
Endothelial P300 promotes portal hypertension and hepatic fibrosis through C‐C motif chemokine ligand 2–mediated angiocrine signaling
Background and Aims During liver fibrosis, liver sinusoidal endothelial cells (LSECs)
release angiocrine signals to recruit inflammatory cells into the liver. p300, a master …
release angiocrine signals to recruit inflammatory cells into the liver. p300, a master …
Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms
Therapeutic inhibition of the histone deacetylases HDAC6, HDAC9, or sirtuin-1 (Sirt1)
augments the suppressive functions of regulatory T cells (Tregs) that contain the …
augments the suppressive functions of regulatory T cells (Tregs) that contain the …
Targeting histone deacetylases in diseases: where are we?
Significance: Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of
human pathologies, in particular cancer. Histone acetylation balance obtained through …
human pathologies, in particular cancer. Histone acetylation balance obtained through …