Protein hydrogels with three-dimensional network structure can be synthesized through both
covalent and noncovalent cross-linking of protein monomers and assemblies, which have …

Self-assembly is a growth mechanism in nature to apply local interactions forming a
minimum energy structure. Currently, self-assembled materials are considered for …

The successful design of a hydrogel for tissue engineering requires a profound
understanding of its constituents' structural and molecular properties, as well as the proper …

Highlights•Hydrogels have revolutionized the field of biomaterials, with peptide and protein-
based systems emerging as versatile platforms.•Stimuli-responsive hydrogels respond to …

Proteins are fundamentally the most important macromolecules for biochemical, mechanical,
and structural functions in living organisms. Therefore, they provide us with diverse structural …

Coiled coils are characterized by an arrangement of two or more α-helices into a superhelix
and one of few protein motifs where the sequence-to-structure relationships to a large extent …

Coiled-coil protein motifs have become widely employed in the design of biomaterials.
Some of these designs have been studied for use in drug delivery due to the unique ability …

Numerous tissues in the human body have fibrous structures, including the extracellular
matrix, muscles, and heart, which perform critical biological functions and have exceptional …

Polymer nanofibers have exceptionally high surface area. This is advantageous compared
to bulk polymeric structures, as nanofibrils increase the area over which materials can be …

Cartilage degeneration and injury are major causes of pain and disability that effect millions,
and yet treatment options for conditions like osteoarthritis (OA) continue to be mainly …