Neuron‐glia interactions in neural plasticity: contributions of neural extracellular matrix and perineuronal nets
E Dzyubenko, C Gottschling, A Faissner - Neural plasticity, 2016 - Wiley Online Library
Synapses are specialized structures that mediate rapid and efficient signal transmission
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …
Development of the vertebrate eye and retina
DL Stenkamp - Progress in molecular biology and translational …, 2015 - Elsevier
The mature, functional, and healthy eye is generated by the coordinated regulatory
interaction of numerous and diverse developing tissues. The neural retina of the eye must …
interaction of numerous and diverse developing tissues. The neural retina of the eye must …
Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses
C Gottschling, D Wegrzyn, B Denecke, A Faissner - Scientific reports, 2019 - nature.com
The synaptic transmission in the mammalian brain is not limited to the interplay between the
pre-and the postsynapse of neurons, but involves also astrocytes as well as extracellular …
pre-and the postsynapse of neurons, but involves also astrocytes as well as extracellular …
CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial microRNA using longer single-stranded DNA
H Miura, CB Gurumurthy, T Sato, M Sato, M Ohtsuka - Scientific reports, 2015 - nature.com
Knockdown mouse models, where gene dosages can be modulated, provide valuable
insights into gene function. Typically, such models are generated by embryonic stem (ES) …
insights into gene function. Typically, such models are generated by embryonic stem (ES) …
Genetic Otx2 mis-localization delays critical period plasticity across brain regions
Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex
(V1) has been implicated in both the onset and closure of critical period (CP) plasticity. Here …
(V1) has been implicated in both the onset and closure of critical period (CP) plasticity. Here …
Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression
FX Blaudin de Thé, H Rekaik, E Peze‐Heidsieck… - The EMBO …, 2018 - embopress.org
LINE‐1 mobile genetic elements have shaped the mammalian genome during evolution. A
minority of them have escaped fossilization which, when activated, can threaten genome …
minority of them have escaped fossilization which, when activated, can threaten genome …
The physiology of homeoprotein transduction
AA Di Nardo, J Fuchs, RL Joshi… - Physiological …, 2018 - journals.physiology.org
The homeoprotein family comprises~ 300 transcription factors and was long seen as
primarily involved in developmental programs through cell autonomous regulation …
primarily involved in developmental programs through cell autonomous regulation …
Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress
Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia
nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more …
nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more …
Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina
Transcription factors (TFs) are often used repeatedly during development and homeostasis
to control distinct processes in the same and/or different cellular contexts. Considering the …
to control distinct processes in the same and/or different cellular contexts. Considering the …
Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development
Photoreceptor development of the vertebrate visual system is controlled by a complex
transcription regulatory network. OTX2 is expressed in the mitotic retinal progenitor cells …
transcription regulatory network. OTX2 is expressed in the mitotic retinal progenitor cells …