A large number of genes associated with various cancer types contain single nucleotide
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …

Colorectal cancer is a complex disease resulting from somatic genetic and epigenetic
alterations, including locus-specific CpG island methylation and global DNA or LINE-1 …

A fundamental goal of epidemiologic research is to investigate the relationship between
exposures and disease risk. Cases of the disease are often considered a single outcome …

DNA damage response genes play vital roles in the maintenance of a healthy genome.
Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant …

The term 'field effect'(also known as field defect, field cancerization, or field carcinogenesis)
has been used to describe a field of cellular and molecular alteration, which predisposes to …

Colorectal cancer (CRC) has predominantly been considered a genetic disease,
characterized by sequential accumulation of genetic alterations. Growing evidence indicates …

Epigenetic modification can mediate environmental influences on gene expression and can
modulate the disease risk associated with genetic variation. Epigenetic analysis therefore …

Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify
disease into molecularly defined subtypes to examine associations with etiologic risk factors …

O6-Methylguanine-DNA-methyltransferase (MGMT) is a unique protein, which both repairs
O6-alkylguanine lesions stoichiometrically without a multi-enzymatic pathway and self …

Constitutional epimutations of tumor suppressor genes manifest as promoter methylation
and transcriptional silencing of a single allele in normal somatic tissues, thereby …