A common feature of pesticides: oxidative stress—the role of oxidative stress in pesticide‐induced toxicity

RO Sule, L Condon, AV Gomes - Oxidative medicine and …, 2022 - Wiley Online Library
Pesticides are important chemicals or biological agents that deter or kill pests. The use of
pesticides has continued to increase as it is still considered the most effective method to …

[HTML][HTML] Microglia in neuroinflammation and neurodegeneration: from understanding to therapy

L Muzio, A Viotti, G Martino - Frontiers in neuroscience, 2021 - frontiersin.org
Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

[HTML][HTML] Inflammation in Parkinson's disease: mechanisms and therapeutic implications

M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

The role of oxidative stress in physiopathology and pharmacological treatment with pro‐and antioxidant properties in chronic diseases

A García-Sánchez, AG Miranda-Díaz… - Oxidative Medicine …, 2020 - Wiley Online Library
Oxidative stress (OS) has the ability to damage different molecules and cellular structures,
altering the correct function of organs and systems. OS accumulates in the body by …

Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention

PR Angelova, N Esteras… - Medicinal Research …, 2021 - Wiley Online Library
The world's population aging progression renders age‐related neurodegenerative diseases
to be one of the biggest unsolved problems of modern society. Despite the progress in …

[HTML][HTML] Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

D Ha, N Yang, V Nadithe - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Exosomes are small intracellular membrane-based vesicles with different compositions that
are involved in several biological and pathological processes. The exploitation of exosomes …

[HTML][HTML] The role of NADPH oxidases and oxidative stress in neurodegenerative disorders

A Tarafdar, G Pula - International journal of molecular sciences, 2018 - mdpi.com
For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases
(NOX) was synonymous with NOX2/gp91phox and was considered to be a peculiarity of …

Exosomes as drug delivery vehicles for Parkinson's disease therapy

MJ Haney, NL Klyachko, Y Zhao, R Gupta… - Journal of controlled …, 2015 - Elsevier
Exosomes are naturally occurring nanosized vesicles that have attracted considerable
attention as drug delivery vehicles in the past few years. Exosomes are comprised of natural …

Differential roles of M1 and M2 microglia in neurodegenerative diseases

Y Tang, W Le - Molecular neurobiology, 2016 - Springer
One of the most striking hallmarks shared by various neurodegenerative diseases, including
Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is …