Metastasis is a complex, multistep process responsible for> 90% of cancer-related deaths. In
addition to genetic and external environmental factors, the physical interactions of cancer …

How adhesive interactions between cells generate and maintain animal tissue structure
remains one of the most challenging and long-standing questions in cell and developmental …

Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary
escalator, intercellular apical junctional complexes which regulate paracellular permeability …

Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to
facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or …

Canonical Wnt signalling has been implicated in mouse and human embryonic stem cell
(ESC) maintenance; however, its requirement is controversial. β-catenin is the key …

The airway epithelium plays a role in immune regulation during environmental challenge,
which is intertwined with its barrier function and capacity to limit submucosal access of …

Traction forces between adhesive cells play an important role in a number of collective cell
processes. Intercellular contacts, in particular cadherin-based intercellular junctions, are the …

Many cell–cell adhesive events are mediated by the dimerization of cadherin proteins
presented on apposing cell surfaces. Cadherin-mediated processes play a central role in …

While breathing, many microorganisms, harmful environmental particles, allergens, and
environmental pollutants enter the human airways. The human respiratory tract is lined with …

Morphogenetic mechanisms such as cell movement or tissue separation depend on cell
attachment and detachment processes, which involve adhesion receptors as well as the …