Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

Organoids have immense potential as ex vivo disease models for drug discovery and
personalized drug screening. Dynamic changes in individual organoid morphology, number …

Comprehensively charting the biologically causal circuits that govern the phenotypic space
of human cells has often been viewed as an insurmountable challenge. However, in the last …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

New discoveries in drugs and drug delivery systems are focused on identifying and
delivering a pharmacologically effective agent, potentially targeting a specific molecular …

Mounting evidence points to causative or correlative roles of gut microbiome in the
development of a myriad of diseases ranging from gastrointestinal diseases, metabolic …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Tumor organoids have emerged as a crucial preclinical model for multiple cancer research.
Their high establishment rates, stability, and ability to replicate key biological features of …