The dopamine transporter (DAT) is a target for the development of pharmacotherapies for a
number of central disorders including Parkinson's disease, Alzheimer's disease …

Background and Purpose Pitolisant, a histamine H 3 receptor inverse agonist/antagonist is
currently under P hase III clinical trials for treatment of excessive daytime sleepiness namely …

Cancer is the second most high-morbidity disease throughout the world. From ancient days,
natural products have been known to possess several biological activities, and research on …

Piperazine-derived diazabicycles are privileged structures found in natural products and
synthetic chemical entities, including therapeutic agents. Herein, we deciphered the …

The Rh-catalyzed C–H alkylation of benzylamine derivatives with unactivated 1-alkenes that
proceeds via a picolinamide directing group is reported. The crucial role of an acid additive …

The Rh-catalyzed C–H alkylation of benzylamines with alkenes using a picolinamide
derivative as a directing group is reported. Both Rh (I) and Rh (II) complexes can be used as …

To investigate structural alterations of the lead triple uptake inhibitor molecule, disubstituted
4-((((3 S, 6 S)-6-benzhydryltetrahydro-2 H-pyran-3-yl) amino) methyl) phenol, we have …

Reactions of a series of 3-oxo-2-arylhydrazonopropanal derivatives with two molar ratio of
ammonium acetate afforded a library of tetrasubstituted 2, 3, 6, 7, 9-pentaazabicyclo [3.3. 1] …

An efficient and stereospecific approach to the synthesis of structurally constrained aza-, oxa-
, and thiabicyclo [3.1. 0] hexane heterocycles has been achieved through application of the …

Stille cross coupling protocols were utilized for the synthesis of 3-(biaryl)-8-oxabicyclo [3.2.
1] oct-2-ene-2-carboxylic acid methyl esters, which furnished products in high yields where …