Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors
produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to …

Background Sarcopenia (loss of muscle mass) is common in cirrhosis and is associated with
poor outcomes. Current teaching recommends the use of protein supplementation and …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis determines patient
prognosis; however, effective treatment for fibrosis has not been established. Oxidative …

As the cirrhosis progresses, development of complication like ascites, hepatic
encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma …

Sarcopenia (loss of muscle mass and/or strength) frequently complicates liver cirrhosis and
adversely affects the quality of life; cirrhosis related liver decompensation and significantly …

The liver is one of the principal organs involved in glucose metabolism together with skeletal
muscle and adipose tissue. A link between diabetes and chronic liver disease (CLD) was …

In the last years the link between the presence of muscular alterations and hepatic
encephalopathy (HE), both minimal and overt, has been deeply studied. The …

Background/Aim: Hepatic stellate cells (HSCs) express α-smooth muscle actin (αSMA) and
acquire a profibrogenic phenotype upon activation by noxious stimuli. Insulin-like growth I …

刘钰懿,陈东风,颜綦先 Page 1 !J&! 肝硬化肌少症的发病机制与诊疗现状 刘钰懿,陈东风,颜綦先
陆军特色医学中心(大坪医院)消化内科,重庆400042 摘要:肌少症是肝硬化患者常见的并发症,发病 …