Plasmacytoid dendritic cells: development, regulation, and function

B Reizis - Immunity, 2019 - cell.com
Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-
derived nucleic acids and respond with rapid and massive production of type I interferon …

The multifaceted biology of plasmacytoid dendritic cells

M Swiecki, M Colonna - Nature Reviews Immunology, 2015 - nature.com
Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the
production of type I interferons (IFNs). pDCs promote antiviral immune responses and have …

Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch

N Liu, VV Hargreaves, Q Zhu, JV Kurland, J Hong… - Cell, 2018 - cell.com
Fetal hemoglobin (HbF, α 2 γ 2) level is genetically controlled and modifies severity of adult
hemoglobin (HbA, α 2 β 2) disorders, sickle cell disease, and β-thalassemia. Common …

Dendritic cell subsets and locations

S Balan, M Saxena, N Bhardwaj - International review of cell and molecular …, 2019 - Elsevier
Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

AL Kalinski, C Yoon, LD Huffman, PC Duncker… - elife, 2020 - elifesciences.org
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …

Transcriptional control of dendritic cell development

TL Murphy, GE Grajales-Reyes, X Wu… - Annual review of …, 2016 - annualreviews.org
The dendritic cells (DCs) of the immune system function in innate and adaptive responses
by directing activity of various effector cells rather than serving as effectors themselves. DCs …

Transcriptional networks driving dendritic cell differentiation and function

SL Nutt, M Chopin - Immunity, 2020 - cell.com
Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of
pathogens to stimulate a robust and appropriate immune response. To initiate responses to …

What makes a pDC: recent advances in understanding plasmacytoid DC development and heterogeneity

A Musumeci, K Lutz, E Winheim, AB Krug - Frontiers in immunology, 2019 - frontiersin.org
Dendritic cells (DCs) are professional antigen presenting cells (APCs) that originate in the
bone marrow and are continuously replenished from hematopoietic progenitor cells …

The role of plasmacytoid dendritic cells in cancers

B Zhou, T Lawrence, Y Liang - Frontiers in immunology, 2021 - frontiersin.org
Plasmacytoid dendritic cells (pDCs) are a special subtype of dendritic cells with the
morphology of plasma cells. pDCs produce massive amounts of type I interferon (IFN-I) …

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease

MD Hoban, SH Orkin, DE Bauer - Blood, The Journal of the …, 2016 - ashpublications.org
Effective medical management for sickle cell disease (SCD) remains elusive. As a prevalent
and severe monogenic disorder, SCD has been long considered a logical candidate for …