The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …

Epithelial–mesenchymal transition (EMT) programs play essential functions in normal
morphogenesis and organogenesis, including that occurring during mammary gland …

Owing to improved early surveillance and advanced therapy strategies, the current death
rate due to breast cancer has decreased; nevertheless, drug resistance and relapse remain …

Cancer is amongst the deadliest and most disruptive disorders, having a much higher death
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …

Abstract Background 14, 15-epoxyeicosatrienoic acid (14, 15-EET) is an important lipid
signaling molecule involved in the regulation of tumor metastasis, however, the role and …

With the expansion of the microbiology field of research, a new genome editing tool arises
from the biology of bacteria that holds the promise of achieving precise modifications in the …

Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer that is frequently treated with chemotherapy. However, many patients exhibit either …

Simple Summary Epithelial–mesenchymal transition (EMT) and its reverse process
mesenchymal–epithelial transition (MET) are considered critical events in the cancer …

One of the fundamental discoveries in the field of biology is the ability to modulate the
genome and to monitor the functional outputs derived from genomic alterations. In order to …

Abstract Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive
breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody–drug …