The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial
barrier during wound healing. Mechanical cues are known to regulate keratinocyte re …

Eating and drinking generate sequential mechanosensory signals along the digestive tract.
These signals are communicated to the brain for the timely initiation and regulation of …

The dynamic epigenetic landscape directs gene expression patterns that dictate cellular
form and function, and drive the assembly of cells into tissues. The high degree of plasticity …

Nearly all structures in our body experience mechanical forces. At a molecular scale, these
forces are detected by ion channels that function as mechanotransducers converting …

A variety of mechanosensory neurons are involved in touch, proprioception, and pain. Many
molecular components of the mechanotransduction machinery subserving these sensory …

Many aspects of mammalian physiology are mechanically regulated. One set of molecules
that can mediate mechanotransduction are the mechanically activated ion channels. These …

The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion
channels that transduce mechanical stimuli with high sensitivity and speed. This conversion …

Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …