The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Abstract γδ T cells play uniquely important roles in stress surveillance and immunity for
infections and carcinogenesis. Human γδ T cells recognize and kill transformed cells …

Cytomegalovirus is one of the most important infections to occur after allogeneic
haematopoietic stem cell transplantation (HSCT), and an increasing number of reports …

Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …

Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …

After more than 60 years of research in allogeneic hematopoietic cell transplantation (HCT),
this therapy has advanced from one that was declared dead in the 1960s to a standard …

Over the last 60 years, more than a million patients received hematopoietic cell
transplantation. Having incorporated multiple changes in clinical practices, it remains a …

Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due
to inadequate restraint of overactivated immune cells and is associated with a variable …

The number of HLA-haploidentical hematopoietic cell transplants continues to increase
worldwide due to recent improvements in outcomes, allowing more patients with …

Graft-versus-host disease (GvHD) was first described in 1959, since then major efforts have
been made in order to understand its physiopathology and animal models have played a …