Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

It is well-established that the chemokine CXC motif ligand 13 (CXCL13) and its receptor, the
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …

Background Chemokine (CXC motif) ligand 13 (CXCL13) was known as a selective
chemotaxis for B cells, a product of follicular helper CD4+ T cells (T FH) and a contributor to …

Myeloid-derived suppressor cells (MDSCs) expand in tumor-bearing host. They suppress
anti-tumor immune response and promote tumor growth. Chemokines play a vital role in …

B cells are recognized as the main effector cells of humoral immunity which suppress tumor
progression by secreting immunoglobulins, promoting T cell response, and killing cancer …

Chemokine CXC motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays
an important role in the immune system. The interaction between CXCL13 and its receptor …

The tumor microenvironment comprises stromal and tumor cells which interact with each
other through complex cross-talks that are mediated by a variety of growth factors, cytokines …

Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

Prostate cancer (PC) is a slowly progressing malignancy that often responds to androgen
ablation or chemotherapy by becoming more aggressive, acquiring a neuroendocrine …

Non-Hodgkin lymphoma (NHL) presents as both localized and disseminated disease with
spread to secondary sites carrying a worse prognosis. Although pathways driving NHL …