Topographical cues, independent of biochemistry, generated by the extracellular matrix may
have significant effects upon cellular behavior. Studies have documented that substratum …

Invasion causes cancer malignancy. We review recent data about cellular and molecular
mechanisms of invasion, focusing on cross-talk between the invaders and the host. Cancer …

Normal human breast epithelial cells show a high degree of phenotypic plasticity in
monolayer culture and express many traits that otherwise characterize tumor cells in vivo …

Cancer cells are genetically predisposed to contribute to the formation of a malignant tumor.
As a population they do not respect tissue boundaries, but penetrate into the surrounding …

The effects of insulin-like growth factor I (IGF-I) on the migration of two human breast cancer
cell lines, MCF-7 and MDA-231, were examined using a modified Boyden chamber. 10 …

An ideal 3D-scaffold for tissue regeneration should have similarity to native ECM in terms of
both chemical composition and physical nanostructure. Recently, nanostructured …

Drug discovery and toxicology is a complex process that involves considerable basic
research and preclinical evaluation. These depend highly on animal testing which often fails …

ABSTRACT Human MCF-7/6 breast cancer cells differ from their MCF-7/AZ counterparts by
their invasiveness in a number of assays in vitro, such as invasion of MCF-7 spheroids into …

✓ Brain tumor dispersal far from bulk tumor contributes to and, in some instances, dominates
disease progression. Three methods were used to characterize brain tumor cell motility in …

BACKGROUND: Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory
effects on the growth and invasive properties of human mammary cancer cells in vitro; …